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By: Bradley G. Phillips, PharmD, BCPS, FCCP

  • Milliken-Reeve Professor and Department Head, Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Athens, Georgia

https://rx.uga.edu/faculty-member/bradley-g-phillips-pharm-d/

They are only efficient towards replicating cells purchase champix cheap, particularly malignancies with a excessive development fraction discount 1 mg champix otc. Cell cycle part particular drug lessons include antimetabolites, bleomycin pep- tide antibiotics, vinca alkaloids (microtubule inhibitors), and etoposide. Cell cycle part nonspecific drug lessons include alkylating brokers, most anticancer antibiotics, cisplatin, and nitrosoureas. Because of this log kill, further rounds of chemotherapy are needed so as to completely eradicate the tumor. Myelosuppression is common as a result of the bone marrow is a rapidly proliferat- ing tissue. The leukopenia is larger than the thrombocytopenia, which is larger than the anemia. Nausea and vomiting are common side effects that may be managed with antiemet- ics, together with: a. Anthracyclines (doxorubicin, daunorubicin, idarubicin, epirubicin and mitox- antrone) are cardiotoxic. Vinca alkaloids (vincristine, vinblastine and vinorelbine); platinum compounds (cisplatin, carboplatin and oxaliplatin); and taxanes (paclitaxel and docetaxel) are neurotoxic. Administering allopurinol (Zyloprim) or rasburicase (Elitek) to deal with hyper- uricemia related to tumor lysis syndrome, especially in leukemia and lymphoma sufferers. Some chemotherapeutic brokers, particularly alkylating brokers, may cause new, remedy-induced cancers as much as several years after remedy. Teratogenicity and carcinogenicity can even occur, again especially with the alkylating brokers. Some cancers are inherently proof against sure brokers; different cancers can develop resistance by mutation, especially after lengthy-term administration of low doses of the drug. Resistance is minimized by short-term, intensive, intermittent therapy with mixtures of medicine. Multidrug resistance occurs due to stepwise selection for the permeability glycoprotein (P glycoprotein). Because P glycoprotein is a multidrug efflux pump, its exercise offers cross-resistance for several structurally unrelated drug lessons. Some organs naturally specific excessive levels of P glycoprotein, together with the kidneys, intestines, liver, and pancreas. Each drug in the combination ought to be energetic towards the tumor to offer max- imum cell killing within the vary of tolerance. The drugs ought to have different mechanisms of motion to kill the maximum num- ber of cells in heterogeneous tumors. The drugs are normally administered in remedy cycles and time must be allowed for host tissue recovery between cycles. They react with nucleophilic groups on nucleic acids and should trigger secondary cancers like leukemias several years after remedy. Mechlorethamine (Mustargen), which is a potent vesicant with a very short half-life (a few minutes). Sufficient hydration and the administration of mesna (Uromitexan) to protect the bladder might help alleviate this side effect. Chlorambucil (Leukeran), is efficient after oral administration and is the slowest-performing and least toxic alkylating agent. Streptozocin (Zanosar) accumulates in the beta cells of the pancreas and might produce insulin shock, an uncommon side effect for an anticancer drug. Busulfan is an orally administered alkylating agent that may trigger myelosup- pression and pulmonary fibrosis. Temozolamide is an analog of dacarbazine and can be metabolized to methylhydrazine. It can be reduced by aggressive hydration and diuresis or administration of amifostine (Ethyol). They are structural analogs of normal metabolites and intrude with purine or pyrim- idine synthesis, as well as with incorporation of nucleotides into nucleic acids. Methotrexate (Trexall, Rheumatrex) is an analog of folic acid which competitively inhibits the enzyme, dihydrofolate reductase. Methotrexate is S-part particular and self-limiting as a result of it slows the move- ment of cells into the S-part. It is metabolized to polyglutamate derivatives that additionally inhibit dihydrofolate reductase and that stay in the cells even in the absence of extracellular drug. Due to low water solubility, crystalluria and renal harm can occur, however these problems can be prevented with urine alkalinization and aggressive hydration. Toxicity can be reversed by leucovorin (citrovorum factor, folinic acid) which is immediately transformed to tetrahydrofolate by an alternative pathway. Purine analogs must be phosphorylated to their energetic kind and are used to deal with leukemias. Thioguanine monophosphate additionally inhibits amidotransferases, which leads to reduced purine synthesis. As a end result, allopurinol will decrease the metabolism and increase the tox- icity of mercaptopurine. Resistance can occur due to down-regulation of the enzyme that phosphorylates the drug, increased dephosphorylation, or increased metabolism of the drug. The phosphorylated kind, fluorodeoxyuridine monophosphate, decreases the exercise of thymidylate synthase. Fluorouracil is often coadministered with leucovorin as a result of leucovorin is required in a coenzyme for thymidylate synthesis. Capecitabine (Xeloda) is an oral fluoropyrimidine carbamate used to deal with metasta- tic breast cancer.

Conversely buy champix mastercard, anxiety issues may sometimes directly set off the development of somatic signs (e generic champix 0.5/1 mg visa. For example, a latest household research found that panic or social anxiety patients and their first-degree relations had been more prone to have interstitial cystitis, mitral valve prolapse and headaches, and this was hypothesized to be linked to a standard genetic susceptibility. Subjects had been blindly interviewed with a diagnostic instrument and medical historical past was obtained by way of medical guidelines and the household historical past display (Talati et al. The condition was not described for the first time till fifty years ago, when it was correctly identified and associated to pathology of the musculoskeletal system (Rotés & Argany, 1957). In 1992, the Hospital del Mar standards (desk 1) compiled all the gadgets included in probably the most clinically used standards. This new scale showed consistent indicators of reliability, internal consistency and predictive validity, and provided proof for using totally different scores according to age and gender (Bulbena et al. Passive apposition of the thumbs to the flexor elements of the forearm (one point for each thumb). Forward flexion of the trunk with knees fully prolonged so that the palms of the hands rest flat on the ground (one point). Passive apposition of the thumb to the flexor facet of the forearm at a distance of lower than 21 mm. Male patients scoring 4 or more are thought of cases; female patients are thought of cases with scores 5 or over. Rotés Querol identified for the first time the exceptional degree of nervous rigidity suffered by patients with hypermobility (Rotés & Argany 1957). To a sure extent, there are some indirect references about the relationship between “hypotonia and anxiety/phobias in the classical psychosomatic literature (Flanders, 1950). On the other hand, Carlsson and Rundgren in 1980 (Carlsson & Rundgren 1980) found a better score in hypermobility among alcoholic patients than among controls. Although not talked about, the percentage of anxiety patients among the many case group might need been excessive. Diagnoses of panic dysfunction, agoraphobia and easy phobia had been considerably more frequent among hypermobile patients. There had been no important variations in the diagnoses of generalized anxiety dysfunction, dysthymia, or main depressive dysfunction. However, this only occurred in 22% of controls, a traditional determine in persistent patient samples. Specifically, agoraphobia and panic issues had been, respectively, 5 and seven times more probably (desk 2). For a subsequent second research, performed to assist this hypermobility-anxiety association, outpatients with new diagnoses of panic dysfunction and/or agoraphobia had been examined, in addition to non-anxious psychiatric and non-psychiatric outpatients as management groups (Martín-Santos et al. Later on, it was advised that this association needed to be studied in the basic population. A sample of 1,300 individuals had been examined at baseline and over 500 had been subsequently subjected to observe-up in a two-stage epidemiological research. No variations had been found for different anxiety issues or mood issues (Bulbena et al. When we compared the groups with and with out joint hypermobility, the imply whole scores for both genders had been considerably higher for the hypermobile group (determine three). The cluster panic dysfunction/phobia had higher scores in concern scales and schizophrenia constructive symptom scales. In 2004, our group also assessed a non-clinical sample of topics working in the same company (N=526) (Bulbena et al. Trait anxiety in 203 girls with or with out joint hypermobility according to all possible cutoff scores on the Hospital del Mar hypermobility standards (Bulbena et al. The primary goal was to find out the cumulative incidence of anxiety issues in a cohort of young topics recruited from the overall population who had not developed any kind of anxiety condition up to then; consequently we planned a scheduled 15-year observe- 110 Anxiety and Related Disorders up covering topics from late adolescence to adulthood. The whole population sample was 1,305 topics, and so as to observe the development of anxiety issues through the 15-year research period, only the lower age section (at the moment topics aged between 16 and 20) included in the cities municipal registry was invited to participate. We sought to describe the prevalence of new cases of anxiety issues through the research period, therefore the exclusion criterion for the research was having already had an anxiety dysfunction at baseline examination. At baseline, 158 topics had been screened for participation in the research, and after the 15-year observe-up the final sample comprised 137 topics (86. Interestingly these authors found an intermediate determine among topics affected by fibromyalgia (25. And finally, Baeza-Velasco and Bulbena also found excessive prevalence of social anxiety and joint hypermobility among topics of excessive stature (Baeza-Velasco & Bulbena 2009). However, under the “modern name dysautonomia not only anxiety features may be found (Bulbena et al, 2004c) but in addition many signs described for greater than two centuries in the present group of anxiety issues (Berrios, 1999). Anxiety manifestations are among the many most difficult to determine in the clinical follow even in patients affected by generalized anxiety dysfunction, during which only 13% present anxiety as primary criticism. Our outcomes address the biological basis of anxiety and a standard source of this condition with different constitutional disturbances in relation to connective tissue and the autonomic nervous system. Anxiety is also a comorbidity and a risk factor in itself for a poor prognosis in a number of psychiatric ailments, as is the case with schizophrenia and bipolar issues. These ailments also present opportunities to further discover the connection between joint hypermobility and the development of anxiety in these circumstances. We strongly advocate screening for joint hypermobility in routine well being evaluation protocols in teenagers and early adulthood topics. In this context, some anamnestic questions may be useful for detecting constructive cases vulnerable to affected by anxiety issues. Conclusions Finally, a number of conclusions may be made after greater than 30 years of lively research and clinical work in that subject.

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If an individual begins to feel higher and stops taking medicine too quickly or too rapidly champix 0.5/1 mg discount, the chance of relapse will increase discount 1mg champix with amex. The determination to cease taking medicine should solely be made in consultation with a physician. The following guidelines may help lower the chance of relapse when an individual desires to discontinue using medicine: • Lower the dosage gradually by “tapering, or reducing, the med- ication over a time period, possibly a number of weeks to months. Side-results typically begin quickly after the person starts treat- ment, and usually diminish over time. In the early levels of treatment, side-results may resemble anxiousness symptoms, causing some folks with anxiousness disorders to abandon the treatment before it has had a chance to take full effect. Some side-results could also be decreased by adjusting the dose, or by taking the medica- tion at a unique time of the day. When taking antidepressants or any medicine, it is important to dis- cuss with your physician any side-results which are troubling you. Check additionally with your physician before using alcohol or illicit medicine, as these can also interact with certain drugs or scale back the effectiveness of treatment. These drugs are identified to scale back symptoms of tension, to be protected, and to have milder side-results than some other antidepressants. The ssris currently available in Canada are: fluoxetine (Prozac), fluvoxamine (Luvox), sertraline (Zoloft), paroxetine (Paxil), citalo- pram (Celexa) and escitalopram (Cipralex). Of these, citalopram (Celexa) and escitalopram (Cipralex) are the latest on the Canadian market and their effectiveness for all anxiousness disorders has not yet been confirmed by way of analysis. These drugs are thought of to be equally effective, though each may go for some folks and never for others. Treatments for anxiousness disorders 29 Common side-results: sexual inhibition, gastrointestinal complaints, weight gain, headaches, anxiousness, insomnia or sedation, vivid goals or nightmares. The solely other medicine in this class currently available in Canada is duloxetine (Cymbalta), which has not yet been studied for effectiveness for anxiousness disorders. Common side-results: nausea, drowsiness, dizziness, nervousness or anxiousness, fatigue, lack of appetite and sexual dysfunction; in greater dosage, venlafaxine may increase blood pressure, and will solely be taken on the medical doctors recommendation by folks with hypertension or liver illness. Imipramine (Tofranil), desipramine (Norpramin) and clomipramine (Anafranil) have been the most studied for the treatment of panic dysfunction, generalized anxiousness dysfunction and posttraumatic stress dysfunction. Common side-results: dry mouth, tremors, constipation, sedation, blurred imaginative and prescient and alter of blood pressure when moving from a sitting to a standing position (orthostatic hypotension). Because 30 Anxiety disorders: An information information tcas may cause heart rhythm abnormalities, ask your physician for an electrocardiogram (ecg) before taking this medicine. If tyramine is taken in a too giant a amount whereas taking an maoi, it could possibly cause severe high blood pressure, which may be life-threatening. You could also be requested to discontinue the maoi prior to the surgery to keep away from possible drug interactions. If you require emergency surgery, your physician will monitor and handle any possible drug interactions during and after the surgery. Common side-results: change of blood pressure when moving from a sitting to a standing position (orthostatic hypotension), insomnia, swelling and weight gain. Mirtazapine (Remeron) and bupropion Treatments for anxiousness disorders 31 (Wellbutrin, Zyban) are newer antidepressants whose effective- ness within the treatment of tension disorders has not been established. They additionally produce drowsiness, making it simpler to go to sleep and to sleep by way of the night. For a very long time, before ssris were available, bzds were the medicine of choice for managing anxiousness dis- orders. However, these medicine have potential for abuse and may be addictive, so the long-time period use of bzds is discouraged. They are usually prescribed along with an ssri or other antidepressant for 2 to 4 weeks at the beginning of treatment, till the antidepressant becomes fully effective. The bzds mostly used to treat anxiousness disorders are clon- azepam (Rivotril), alprazolam (Xanax) and lorazepam (Ativan). Common side-results: drowsiness, sedation, dizziness and lack of steadiness; results are most severe when bzds are mixed with alcohol or with other sedative drugs. It works mainly by way of the serotonin neurotransmitter sys- tem and usually takes two to 3 weeks to become effective. Although many crops may have energetic ingredients that may be somewhat effective in relieving various symptoms, their effectiveness has not been formally take a look at- ed. Some natural products have sedative results and are believed to scale back symptoms of tension. These embrace German chamomile, hops, kava kava, lemon balm, passion flower, skullcap and valer- ian. The strategy of achieving this goal, known as “restoration, typically includes a combination of medicine, cbt and supportive psychotherapy, and can also embrace other support such as occupational, recreation and nutri- tion remedy. Recovery additionally consists of the way you apply the talents realized in treatment to actual-life conditions. Long-time period targets may embrace improved relationships with others, a full and satisfying work life, elevated self-esteem and improved overall high quality of life. To stop relapse, you need to be ready with a plan to handle symptoms as they appear. Moving by way of the process of restoration and relapse prevention is determined by a combina- tion of planning and attitude. Achieving and maintaining your targets is less complicated if you develop: 34 Anxiety disorders: An information information • consciousness of warning signs and strategies to respond to setbacks • a healthy life-style • hope and optimism concerning the future • self-confidence. Many resources can be found, including books, videos, support teams and information on the Internet. Be conscious that not all Internet sites provide dependable information; see the resources section starting on page 49, for beneficial sites and other ideas for additional information. Maintaining enhancements in symptoms of tension requires commitment and dedication.

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Inhibition of the platelets and erythrocytes aggregation and adhesion order 0.5/1mg champix, normalization of the blood Pharmacological effects Fibrinolytic effect (1-three) purchase champix 1 mg with visa. Thrombosis of veins, arteries; fresh cardiac Prophylaxis and treatment of hypercoagulation syndrome, continual coronary deficiency (four-9). Indications and infarction, thromboemdolism of pulmonary Ischemic encephalopathy, retinopathy (four-8). Fibrinolytics are used in fresh (as much as 5 days) thromboses with anticoagulants beneath the strict management of blood coagulation markers. Fibinolytics are contraindicated in case of bleedings, peptic ulcer, radiation illness, tuberculosis. Doctor and pharmacist, Dipyridamols effect decreases in case of caffeine and different xanthine derivatives affect. Nettle herb** Block of the plasminogen activation, Participation in blood coagulation as natural parts of Decrease of the vascular wall Mechanism of motion inhibition of plasmin capabilities, kinin the coagulation system (four,5,6,8,9). All types of interchangeability thrombocytopenia (1,three); bleedings in peptic uterine bleedings (7,10-13). Tranexamic acid answer mustnt be combined with options containing penicillin, blood products in a single syringe. Molgramostim* (Leukomax) Stimulation of hemopoietic exercise of the bone marrow Increase of hemoglobin content in Improvement of iron utilization and stimulation and leucopoiesis; increase of macrophages, Pharmacological effects erythrocytes (1-5). Leukopenia, agranulocytosis (12-14); immunity Hypochromic and hyperchromic anemia, decrease, radiation illness (10-12,15); viral hepatitis Indications and hepatitis, hepatic cirrhosis, helminthiasis, states Iron-deficiency anemia (1-5). Iron-containing medicine are incompatible with salicylates, cardiac glycosides, antacids. Doctor and pharmacist, Vitamin B12 (cyanocobalamin) mustnt be injected with different medicine in the one syringe. Iron-containing medicine trigger constipation, staining of excrements and enamel in black colour (after taking in these medicine one ought to rinse the mouth). Pharmacological effects Antitumor (1-75); cytostatic, cytotoxic, immunosuppressive (1-44) effects. Amino- (Megeyse) phosphate (Mammofen) propionate (Anandrone) (Zolagex) glutethimide 46. Pharmacological Antiandrogenic (48-fifty two,fifty seven-59); androgenic (fifty five,fifty six); estrogenic (48-fifty two); antiestrogenic (45-47,fifty three,fifty four,63,64) effects; pharmacological castration (60-62). Pharmacological effects Cytostatic, cytotoxic, immunosuppressive (sixty five-75); antimicrobial (sixty five-73) effects. Leukemias (1-three,6-8,11-14,19,22,24-28,32,34,35,37-39,41,sixty six,sixty nine-71,72) Erythremia (10) Uterus carcinoma (1,7,20-22,24,31,33,35,45-47,fifty three-fifty five,sixty five-sixty seven,sixty nine,71,75) Ovarian carcinoma (1,three,5-9,12,20-22,31,33,34,forty three-47,fifty three-fifty five,sixty five,sixty seven,sixty nine) Stomach carcinoma (15,sixteen,21,30,31,38,41,sixty five-sixty seven,sixty nine,75) Prostate carcinoma (7,21,22,31,48-64,sixty seven,sixty nine) Mammary gland carcinoma (1,2,5,7-9,15,21-23,30,31,34-37,forty three-47,50, fifty three- Sarcoma (1,four,5-8,sixteen,21,22,34,35,37,38,41,sixty five,sixty seven,sixty nine,73) fifty six,63,sixty six,sixty nine,70,73) Urinary bladder carcinoma (7,8,20-22,31,34,35,38,39,41,sixty six,sixty nine) Lung carcinoma (1,four,7,8,15,17,19,20-22,23,29,31,34-38,39,41,forty three,44, Skin most cancers (42,sixty seven,sixty eight,70) sixty six,sixty seven,sixty nine,70,71,73-75) Pancreas carcinoma (1,29,31,sixty six,sixty eight,sixty nine) Lymphogranulomatosis (2-four,6-8,15,sixteen,19,21,28,34,35,38,41, Liver carcinoma (sixteen,22,31,sixty nine,70,72) Indications and sixty five,sixty seven,sixty nine,73) Testicle carcinoma (1,5-7,20-22,34,38,41,sixty five,sixty seven) interchangeability Cerebral tumor (5,15-18,30,34,35,39,sixty seven,sixty eight,70,71,seventy four,75) Renal carcinoma, renal carcinosarcoma (Wilms tumor) (7,15,22,34,35,41,sixty five,sixty seven, Melanoma (5,15-19,35,37,sixty five) sixty nine,71,72) Rectum and enormous intestine most cancers, colorectal carcinoma (22,30,31,35,sixty six- Head and neck carcinoma (20-22,31,34,35,37,44,sixty six,sixty seven,sixty nine,seventy four) sixty eight,75) Adrenal cortex carcinoma (21,63,64) Esophageal carcinoma (17,22,37,40,sixty seven) Ewings tumor (1,7,35,38,41,sixty five,72) Penis carcinoma (sixty seven) Multiple myeloma (5,7,15,sixteen,22,35,sixty nine) Thyroid gland carcinoma (5,sixty seven,sixty nine) One ought to keep away from to use simultaneously melphalan and nalidixic acid. Carboplatin is incompatible with medicine, causing myelosuppressive, nephro- and neurotoxic effects. Vinblastine shouldnt be combined with medicine, having the pH past the bounds of 3,5-5, in a single syringe. Doctor and pharmacist, Vincristine answer is incompatible with furosemide answer in a single syringe. Nimustine, etoposide, trexan options mustnt be combined with different medicine options in a single syringe. Phosphestrol mustnt be combined with options, containing calcium and magnesium salts, in a single syringe. Epirubicin shouldnt be combined with heparin answer, different antitumor medicine in a single syringe. Plantaglucide** Formation of albuminates Neutralization of the Block of H2-histamine (1-three), M1- (protection of the hydrochloric acid in Stimulation of regenerative cholinoceptors (four) of gastric gastric mucous Bactericidal effect on Mechanism of motion stomach, overlaying of the processes in stomach (12, mucous membrane. Gastroprotective, Gastroprotective, antisecretory (12-13); Antisecretory (hydrochloric acid, Covering, antacid (6-9) antibacterial, astringent, antacid (14-sixteen); Pharmacological effects pepsine) (1-5); spasmolytic (four); Antibacterial (18-20) effect. Indications and Peptic ulcer (1-20); hyperacid gastritis (1-sixteen, 18-20); hypoacid gastritis (17); gastroesophageal reflux, Zollinger – Ellisons syndrome (1-5). Antacids ought to be taken 1,5-2 hours before or 1,5-2 hours after taking different medicine. Cimetidine must not be taken along with benzodiazepines, oral anticoagulants, propranolol, verapamil, cytostatics and hemopoiesis inhibitors. Doctor and pharmacist, the extended administration of De-nol and Venter ends in scarry deformations of the stomach and duodenum. Ursodeoxycholic acid Normalization of metabolic processes in hepatocytes; stabilization of hepatocytes cell membranes; decrease of free radical oxidation processes in Mechanism of motion hepatocytes. Hepatoprotective (1-35) Spasmolytic (7,9,35) Antiulcer (four, 15) Antioxidant (1,7,9,15,24,25,30) Antimicrobial (9) Antianemic (14) Antitoxic (1,5,6,September 11, 15,19,21,22,31,34) Cholelitholytic (10,32) Cardioprotective (22,25) Pharmacological effects Choleretic (2,four,5,7,9,10,24,25, 31,35) Immunomodulating (15,24) Anabolic (25,29) Membrane-stabilizing (1,four,6,7,9,22,24,25,30,32) Anti-inflammatory (1,four,10,15,24) Antipyretic (24) Regenerative (7-9,11,29,35) Antidepressant (sixteen) Antianorectic (6,8). Analgesic (9,24) Diuretic, laxative (8) Chronic hepatitis (1-5,8,9,11-14,17-19,22,24,25,28,30-32,34) Cholestatic hepatitis (2,sixteen,35) Hepatic cirrhosis (1-three,8,11,12,sixteen,18,20,22-24,27-29,30-32) Hypoacid gastritis (13,14) Acute hepatitis (8,9,12,17-19,24,29,33) Indications and Renal failure (5) Cholecystitis (four,5,9,33,34) interchangeability Hypercholesterolemia (26,34) Biliary dyskinesia (four,5,7,9) Peptic ulcer (four) Hepatic coma (18-21) Anemia (14). Pancreatitis (13,33) In order to organize Essentiale answer for intravenous injection, one mustnt use electrolytes options. Doctor and pharmacist, Heptral isnt beneficial to use before bedtime, due to its tonic effect. Castor oil Increase of osmotic Irritation of intestinal Mechanical stimulation of Depending on the drug Mechanism of motion stress in Feces softening. Constipations on account of intestinal hypotonia and weak intestinal peristalsis (1-13). Indications and Stool regulation in hemorrhoid, proctitis and anal fissures (1, 2, 5, 7, 13). Administration of sodium picosulfate with antibiotics may cause decrease of laxative effect.

References:

  • https://academic.csuohio.edu/kneuendorf/SkalskiVitae/SkalskiNeuendorfCajigas17.pdf
  • https://www.mskcc.org/sites/default/files/node/158749/document/msk-17ar-final-pdf.pdf
  • https://www.psychiatry.org/File%20Library/Psychiatrists/Meetings/Annual-Meeting/2019/AM2019-Guide.pdf
  • https://core.ac.uk/download/pdf/8665753.pdf
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