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  • Professor of Biochemistry and Biophysics
  • Associate Director, Cardiovascular Research Institute, University of California, San Francisco

https://profiles.ucsf.edu/john.kane

In 1963 medrol 16mg sale arthritis hip pain exercises, the outcomes of a startling psychological experiment supplied proof of this conjecture (Figure 31) buy genuine medrol arthritis in neck causing numbness in hands. These individuals obeyed only as a result of they were told to take action, not as a result of they were underneath any specific threats (Figures 32-34). In 1973, British playwright Dannie Abse produced a play, ?The Dogs of Pavlov,? based on Milgram?s work. Military Academy launched two new necessary psychology courses based on Milgram?s work. In 1986, musician Peter Gabriel recorded a music, ?We Do What We?re Told (Milgram?s 37). Scott Peck echoes the identical theme heard in Milgram?s work in his own guide (Figure 35): Whenever the roles of people within a bunch turn into specialized, it becomes each attainable and simple for the person to move the ethical buck to some other part of the group. In this fashion, not only does the person forsake his conscience however the conscience of the group as a complete can turn into so fragmented and diluted as to be nonexistent?. The more this individual has to lose?each in prestige, money, and future success?the much less doubtless he or she is to risk such a loss. One of my sufferers, Betty Martin, who can also be a former schoolteacher and who was born on November 22, gave this to me just some days in the past. This evaluation included the pictures, X-rays, clothes, magic bullet, and two metallic fragments faraway from the skull. During this six -yr time interval my preliminary findings had been published in two books: (1) Assassination Science (1998) and (2) Murder in Dealey Plaza (2000), each edited by James Fetzer. To place the numerous discoveries of this ninth and last visit in context, the major conclusions from my preliminary eight visits are first summarized. All readers ought to note that extra conclusions of somewhat lesser significance either have been or shall be summarized elsewhere. This left unaltered a large, darkish space on the front of the skull, which made it appear that a posterior bullet had blown out the front. An apparent corollary to this conclusion is that each unique, lateral skull X-rays have vanished?with no hint. Shortly after the post-mortem-through the use of a simple, double exposure approach at midnight room?a 6. This X-ray forgery was done with a single purpose: to incriminate Oswald via the 6. Even more to the point, this object played an important role in their conclusions ?which have now been thoroughly undermined. This is in dramatic disagreement with the mind photographs, which show practically intact mind on either side of midline. This latter conclusion, particularly, is in serious disagreement with the mind photographs. On the other hand, one of many Parkland nurses, who appeared inside the skull while getting ready the physique for departure, truly noted that a big quantity of the left mind was additionally lacking. The black and white prints of the X-rays, listed in Burkley?s Memorandum of Transfer (26 April 1963), now not exist. Based on 3D viewing of the post-mortem photographs with a large format stereo viewer, the scalp hair on the posterior head photographs (b & w # 15, 16 and shade # forty two, forty three) appears starched and flat, i. These observations were made with a magnifying lens that integrated two different powers. Humes, made comparable denigrating comments in regards to the supposed entry site on the b & w pictures. When the anatomic landmarks from the skull X-rays are integrated with comparable landmarks from 3D viewing of the thriller photographs of the big skull defect a transparent conclusion emerges: the big skull defect must lie on the proper rear?in hanging settlement with just about all the Parkland and Bethesda medical personnel. There are only seven distinctly different post-mortem poses of the physique; all of these could be seen in popular books. Likewise, the re are seven shade pictures of the mind, none of which is within the public record. No fabric appears to be lacking?that means that a scalpel would possibly properly have produced these slits (as has been recounted by the nurses, who cut off the clothes). The look of these slits is by no means according to the passage of a bullet (and no checks ever showed the presence of metallic at this s ite). In order to clarify the low-lying gap within the coat, partisans of the only bullet theory have essentially had to argue that the highest of the coat was bunched up (by more than four inches) in accordance with the measurement noted simply above. No checks performed on this fragment can explain its odd transformation in shape and dimension, nor has forty one any official rationalization ever been superior for its current, and dramatically different, shape. There are remarkably many, tiny metallic fragments broadly scattered on the skull X- rays -even on the left aspect and on the inferior skull, together with no less than four near the chin on the frontal X-ray. This exceptional, and heretofore ignored, observation is hardly suitable with the passage of a single, full metallic-jacketed, Mannlicher-Carcano bullet near the highest of the skull, however would possibly more simply have resulted from a hole point or mercury bullet?or perhaps even from shrapnel from a bullet that was not counted by the Warren Commission. All three skull X-rays show a (spatially constant) fuzzy, grey cloud throughout the fragment path that extends across the highest of the skull; this fuzzy cloud seems more according to mercury (extruded from a bullet) rather than lead. I am, however, unaware of any existing experiment with mercury bullets shot into skulls that could test this conclusion; this could therefore be considered as a substitute as a speculation ripe for experiment. There are 20 shade transparencies (this was the one shade format exposed in the course of the post-mortem) of the physique, and 18 b & w negatives, yielding a complete of 38 pictures of the physique. On 19 May 1969, however, pathologists Humes and Boswell noted that one shade unfavorable of the mind (#forty nine) was lacking.

Earlier recognition of at-risk individuals with screening and the next investigation of a large spectrum of preventive and corrective measures are really helpful buy generic medrol arthritis in fingers nhs. Screening for hypertension For screening purposes discount 4mg medrol with amex healing arthritis with diet, the next pointers are really helpful:. Total cholesterol classification Total cholesterol (mmol/L) Total cholesterol (mg/dL) Classification <5. Triglycerides classification Triglycerides (mmol/L) Triglycerides (mg/dL) Classification <1. The frequency could also be decreased to each different 12 months for patients with optimal lipid ranges. Screening is necessary in order to identify patients with suboptimal lipid profiles and institute corrective measures for either major or secondary prevention. Brittle diabetes [23] Brittle diabetes refers to patients with type 1 diabetes mellitus who exhibit broad and extreme fluctuations in blood glucose despite efforts to modify and adjust their day by day activities, meal planning and insulin routine. They have widespread occurrences of hypoglycaemia, frequently extreme hyperglycaemia and episodes of diabetic ketoacidosis. Treatment of patients on this category has been a frustration for most well being-care suppliers. The reason for the brittleness is unclear, however could also be due to a mix of psychosocial, way of life, neurohumoral and hormonal abnormalities. Chapter four Screening for diabetes mellitus Background the question of mass group screening for diabetes stays controversial. The underlying philosophy of screening has been that detection of diabetes in asymptomatic or minimally symptomatic individuals will result in efficient remedy which will retard its progression and scale back the risk or the severity of issues, thus diminishing untimely morbidity and mortality. This is introduced into focus by the frequent presence of specific issues at the time of medical prognosis and the estimate that on common topics had had type 2 diabetes mellitus for four?7 years previous to prognosis [21,23]. Initially it was widely really helpful, nonetheless at current it is strongly recommended only for individuals at risk or for epidemiological studies. Such information are essential for public well being planning and provide data for continued analysis of the present diagnostic standards. Screening programmes can also enhance group awareness and pave the way for schooling about diabetes. Important considerations in the design of an applicable screening programme include [21,23]:. Therefore applicable explanations and procedures ought to be incorporated into the screening protocol and programme design to minimize antagonistic effects and to address them when they do occur. It have to be emphasised that screening is just worthwhile if an effective intervention may be launched to decrease the burden of the disease or prevent its issues. The present state of information suggests that definitive proof of the value of screening is lacking, however proof in its favour is steadily accumulating. Screening approaches A positive result in a screening check signifies only a high chance of the person having the disease. There are three completely different approaches to screening: inhabitants, selective and opportunistic. Population screening [21] Population screening is worth it only for well being care planning, for epidemiological research purposes or in high-prevalence populations. Selective screening [21] Selective screening is undertaken in teams identified to have risk factors for creating type 2 diabetes mellitus. Opportunistic screening Opportunistic screening occurs when high-risk individuals current themselves to some sector of the well being care system. It is probably the most employed method and is very price- efficient in that no assets are needed to organize the screening or call for topics [21]. Alternatives, such as measurements of glycated haemoglobin, glycated proteins and 1,5-anhydroglucitol, although specific, are too insensitive to reliably detect lesser levels of glycaemic disturbances. There are many strategies out there for measuring blood glucose, starting from visually-read check-strips to stylish automated strategies. When automated procedures are used, care have to be taken to minimize the risk of errors in pattern identification. Fasting plasma glucose Fasting is defined as avoiding the consumption of any meals or beverage apart from water for no less than 10?sixteen hours earlier than testing. Interpretation of fasting blood and plasma glucose ranges [21?23] Fasting plasma glucose Interpretation <5. A positive urine check outcome signifies the need for confirmatory blood glucose testing [22]. Proper coaching is required for those conducting the screening, and the importance and relevance of the diagnostic programme to well being care ought to be made explicit. Every screening programme must have an established mechanism for follow-up and additional analysis of those with a positive outcome. To be more specific, a screening programme ought to identify individuals with a number of diabetes risk factors. Individuals with a couple of risk issue ought to be referred for analysis and testing. Screening for type 1 diabetes mellitus [23] Given present information, screening may be really helpful only for research purposes associated to the prevention of type 1 diabetes mellitus. Different screening approaches can 32 Guidelines for the prevention, administration and care of diabetes mellitus be applied relying on the actual research question. Screening for type 2 diabetes mellitus [23,25] the principle causes for the present curiosity in screening for type 2 diabetes are:. Screening of asymptomatic adults for type 2 diabetes mellitus ought to be carried out in the following teams, and if normal ought to be repeated every three years. Evaluation [23] Screening for diabetes is justified on the grounds that early detection permits efficient early intervention, thus diminishing the likelihood of the event of issues.

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Do not use as frst line therapy in African or Caribbean household origin risk of angioedema 1 medrol 16 mg online arthritis muscle pain relief cream ointment. Check for possible adverse effects of antihypertensive drug remedy including the risks from unnecessarily low blood stress order medrol 4mg with visa arthritis vegan. Patients with Type 2 diabetes regularly have refractory or resistant hypertension despite the use of three or 4 blood stress agents. If this is the case then search expert recommendation from a advisor endocrinologist as per national mannequin of care. All remedy should once more be given at the side of recommendation on food plan, decreased alcohol intake, exercise and weight reduction where appropriate. Type 2 diabetes is associated with an increased risk of cardiovascular and cerebrovascular occasions. Aspirin (75-150mg/day) must be prescribed in patients with diabetes and a historical past of cardio or cerebrovascular disease (secondary prevention). Clopidogrel (75mg/day) must be used as an alternative of aspirin only in these with clear aspirin intolerance and aspirin allergy. Combination therapy with Aspirin (75mg/day) and Clopidogrel (75mg/day) may be maintained for up to 12 months after an acute coronary syndrome. Source: National Clinical Programme Diabetes Smoking It has been proven that smokers have poorer glycaemic control than non-smokers or ex- smokers. Smoking affects the body?s metabolic control, will increase insulin resistance and interferes with the motion of insulin within the body. Research has proven that smokers with diabetes have a heightened risk of morbidity and premature death associated with the development of macrovascular issues. Smoking is also associated to the premature improvement of microvascular issues. Monitoring Patients must be asked about their smoking habits at each clinic go to. Treatment Non Pharmacotherapy Some of the best methods of serving to smokers to quit embody temporary intervention recommendation. One of the most important aspects about advising or giving assist is to determine where the person is in relation to the cycle of change as outlined by Prochaska and Diclemente (1983), Cycle of Change. Smoking cessation counselling and different forms of remedy must be included in routine care. However the analysis suggests that the extensive benefts of quitting versus the heightened risks of constant to smoke, should guide the choice relating to use of nicotine substitute therapy and different pharmacological aides for cessation. Therapy in a type acceptable to the patient must be supplied for appropriate size of time. Rigorous studies of their short and lengthy-time period effects are needed in determining their safety and effcacy and their cardiopulmonary effects as compared with smoking and normal approaches to smoking cessation7. Lipids the guidance in relation to primary prevention of vascular risk elements is previously outlined. Lifestyle modifcation specializing in the discount of saturated fats, trans fats, and cholesterol intake; improve of omega-three fatty acids, fbre, and plant stanols/sterols; weight reduction (if indicated); and increased bodily activity must be beneficial to enhance the lipid profle in patients with diabetes7. Consider add on therapy if after 4 months on maximum dose statin lipid targets not achieved. All remedy should once more be given at the side of recommendation on food plan, decreased alcohol intake, exercise and weight reduction where appropriate. Patients with diabetes have a 10 to twenty-fold increased risk of lower limb amputation in comparison with non-diabetic patients. Neuropathy and peripheral disease are the principle pathologies underlying diabetic foot problems:. These pathologies can result in ulceration, an infection, gangrene, and amputation Diabetic foot ulcers are vulnerable to an infection, typically with polymicrobial invasion. Foot infections are a significant explanation for hospital admissions among folks with Type 2 diabetes and an essential explanation for lower limb amputation. All patients with diabetes should have their foot examined at each clinic go to as per the national mannequin of foot care to look for the presence of neuropathy, ischaemia or deformity. Referral pathways exist between indicative mannequin three and mannequin 4 hospitals at a regional mannequin (refer to national foot mannequin). High risk foot patients must be referred to the hospital diabetes multidisciplinary foot protection staff/specialist foot service and be seen inside 4 weeks. Moderate risk patients must be referred to the podiatrist either locally or within the hospital diabetes foot protection staff/specialist foot service and be seen inside 4 weeks ideally. Algorithm for the assessment of diabetic foot is on the market in Appendix 5 Foot Care Patient Education Education plays a primary role within the prevention of ulcer recurrence. This should encompass foot hygiene, the need for daily foot inspection, appropriate foot wear, immediate remedy of new lesions, and the significance of standard podiatric visits. Foot Care schooling improves the knowledge and behaviour in direction of foot care within the short time period in folks with diabetes. The provision of orthoses or therapeutic shoes or both can reduce irregular foot stress, callus formation and due to this fact ulcer improvement. Eye Disease Diabetic Retinopathy Diabetic retinopathy is likely one of the commonest causes of blindness within the working age population in Ireland. Up to 10 per cent of individuals with diabetes are susceptible to sight threatening retinopathy. Diabetic retinopathy might not have any symptoms or might not affect sight in its early stages.

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These cancers slowly regress after radiation therapy typically requiring more than a year to obtain the maximum response order medrol 16 mg without prescription arthritis in dogs ibuprofen, analogous to the scenario 131 when I is used to deal with gross illness purchase generic medrol online arthritis in neck of dogs. Radiation therapy is particularly useful for treating the thyroid mattress when residual microscopic illness is suspected. Under best clinical circumstances, nevertheless, this will be a uncommon requirement, as patients ought to have sufficient surgical elimination of gross thyroid tissue adopted by radioiodine treatment. However, growing knowledge of the specific genes concerned in thyroidal oncogenesis could contribute to the future improvement of more effective treatment modalities [13. Lymphoma Combined chemotherapy and irradiation are efficient in thyroid lymphoma [13. Consequently, whole thyroidectomy ought to not be thought of the first-line treatment. Other histologic varieties, including Hurtle cell carcinoma are characterized by superior illness at the time of diagnosis and by could also be unresponsive to treatment. Mucositis requiring supportive treatment including intravenous fluid, soft diet and analgesic;. Lhermitte?s syndrome consists of sensation felt like an electric shock down the again and into the legs on flexing the pinnacle briskly. Most differentiated thyroid carcinomas may be efficiently handled by the mix of surgery, radioiodine and L- thyroxine suppressive therapy. The position of chemotherapy is restricted to the treatment of i) regionally superior or metastatic nonfunctioning or non-iodine concentrating differentiated thyroid most cancers, ii) anaplastic thyroid cancers, and iii) superior metastatic medullary thyroid cancers. Chemotherapeutic brokers are used both as monotherapy or in combination with more than one drug. Addition of chemotherapy to surgery and exterior radiotherapy is reported to enhance the survival in medullary thyroid most cancers [14. Only relatively few patients have acquired chemotherapy for regionally superior carcinoma or metastatic illness. The first chemotherapeutic agent to be used to deal with differentiated thyroid cancers was bleomycin. Another drug used more extensively with some success, probably best mono-chemotherapeutic agent used so far, was Doxorubicin. The overall response fee reported in 83 patients of differentiated thyroid cancers from eight research was 38. Further, Doxorubicin therapy is 2 related to cardiotoxicity occurring at doses of 550 mg/m and above. Other chemotherapeutic brokers used have been methyl-chloroethyl-cyclohexyl-nitrosourea, Rubidazone, peptochemiol, Aclarubicin, Mitoxantrone, endoxan and Pepliomycin [14. These medication have been both ineffective or had very limited, non-lasting effects on the tumour suppression. Since a single agent was not efficient and related to unwanted side effects, multi-drug therapy 2 using various mixture of drugs and dosages have been examined. The outcomes have been disappointing and common response fee of multiple-agent chemotherapy seems to be solely barely higher than that of doxorubicin single-agent chemotherapy. Anaplastic most cancers In distinction to the indolent differentiated kind, anaplastic giant cell thyroid carcinoma is likely one of the most aggressive tumours in people. In the management of anaplastic most cancers, chemotherapy is more regularly used as these tumours do 131 not focus I and are more typically unresectable. Doxorubicin monotherapy alone or in combination with exterior radiotherapy has resulted in a response fee various between 10-22% [14. Treatment with Bleomycin confirmed a partial response fee of 25% in major tumours and 50% in lymph node metastases [14. Aclarubicin was found to be ineffective with a brief partial response of solely 14% [14. Methotrexate (5 mg/day, for 5 days) treatment with exterior radiotherapy (40 Gy in divided doses over 5-6 weeks) in 5 patients has been reported to end in complete regression of major tumour. However, patients had severe unwanted side effects they usually died because of local tumour recurrence and pulmonary metastases within 5-13 months [14. Sixteen patients have been handled with pre- and postoperative doxorubicin and hyperfractionated radiotherapy. Of these, 5 patients had a whole remission, and two patients survived more than 2 years [14. They found the response fee to be considerably higher in combined drug therapy as compared to monotherapy. Although, they found complete response in 18%, which lasted for more than 1 year, seventy three% of instances had a progressive illness indicating the ineffectiveness of the treatment. However, most of their patients developed distant metastases and died (median survival 1 year). A greater success fee (4 with complete response and 5 with partial response in a complete of 10 2 evaluable instances) has been reported using multimodal treatment with doxorubicin (60 mg/m) 2 and cisplatin (90 mg/m) together with a cut up course of exterior radiotherapy [14. This regimen was efficient in longer survival and native control, but was ineffective in controlling distal metastases. They obtained complete local remission in 48% and 4 patients survived for more than 2 years with no proof of illness. A whole of sixteen patients (Group 1) have been handled with whole thyroidectomy, radiotherapy and chemotherapy with adriamycin and bleomycin in various order. Nine patients with distant metastases at diagnosis (Group 2) acquired chemotherapy; considered one of them had a disappearance of lung metastases and was then handled by whole thyroidectomy and further chemotherapy.

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Low cardiorespiratory ftness and physical activity as predictors of mortality in males with sort 2 diabetes purchase medrol 4 mg on-line arthritis knee footwear. Physical activity recommendation only or structured train training and affiliation with HbA1c ranges in sort 2 diabetes: a scientific evaluate and meta-evaluation discount medrol line arthritis diet and supplements. Position statement: bariatric surgical and procedural interventions in the remedy of obese patients with sort 2 diabetes. In very limited settings diabetes control could need to be based on measurement of plasma glucose ranges alone. Capillary blood glucose strips measure the glucose in the plasma of the capillary blood sample, however may be calibrated to provide results both as plasma or typically complete blood glucose (examine meter instructions). The concern then arises as to the desirable stage of plasma glucose control to be achieved. In a perfect world this would be ?normal?, but when the obtainable way of life and pharmaceutical therapies are lower than optimum in terms of effcacy and adverse effects on quality of life (well being achieve versus well being value), or if these therapies are expensive, then some compromise (varying between individuals and well being-care systems) shall be wanted. The chosen measures of glucose control (HbA1c and self-monitoring) are discussed elsewhere (see Chapter 7: Clinical monitoring and Chapter 8: Self-monitoring). The idea of targets is open to criticism they might be unattainable, they might limit what might be attained, and so they may be uneconomic to realize. However, with out some type of targeted control of an asymptomatic condition it becomes diffcult to advertise care at all. Evidence-base Guidelines range in their recommended general HbA1ctarget however most advocate a target of 7. Intervention research which have achieved and maintained fixed HbA1c ranges throughout the research period can inform the question of optimum HbA1c targets. However results may be confounded by differences in the therapies utilized in totally different remedy arms. The Kumamoto research [8] in non-obese insulin-requiring Japanese folks with sort 2 diabetes achieved and maintained in the course of the 6 year research period a imply HbA1c of 7. For microvascular problems, neither the frst (dialysis or renal transplantation, high serum creatinine, retinal photocoagulation or vitrectomy) nor second composite outcome (frst composite outcome plus peripheral neuropathy) have been signifcantly totally different. However intensive remedy delayed the onset of albuminuria and some measures of eye problems and neuropathy [10]. There was no signifcant difference in major macrovascular outcomes or dying between the teams, however major microvascular occasions have been signifcantly lowered in the intensive-control group, primarily as a result of a discount in the incidence of nephropathy. There was no difference in the main outcome or in microvascular problems, although there was a signifcant decrease in albuminuria in the intensive-remedy group [12]. Better glycaemic control is essential to minimise diabetes-related microvascular and macrovascular problems. However latest research have failed to supply conclusive ends in favour of tight versus commonplace glycaemic control and including further glucose-lowering remedy beneath 7. Little proof subsequently helps improved outcomes to beneath an HbA1c target of 7. Regression equations between capillary-measured plasma glucose and HbA1c at the moment are better established [14]. Overall the case is compelling, not least by the straightforward logical observation that the result trials have established the utility of lowering blood glucose ranges total, while the highest ranges of the day are typically after meals. However post-challenge ranges seem intently related to different cardiovascular threat elements. Implementation these intervention ranges and targets must be incorporated in native protocols and guidelines detailing strategies for evaluating and advising on way of life and pharmaceutical therapies as the natural history of the condition evolves. Evaluation Glucose targets (as given above) must be present in native guidelines and protocols. Potential indicators Data to be collected Indicator Denominator Calculation of indicator for calculation of indicator Number of people with Total number of Percentage of people sort 2 diabetes with Most latest HbA1c folks with sort 2 with sort 2 diabetes with HbA1c < 7% / 53 mmol/ measurement in the diabetes attending HbA1c < 7. Number of people with Total number of sort 2 diabetes with Percentage of people folks with sort 2 Most latest HbA1c HbA1c? Canadian Diabetes Association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Intensive insulin remedy prevents the development of diabetic microvascular problems in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year research. Intensive blood glucose control and vascular outcomes in patients with sort 2 diabetes. Position statement: bariatric surgical and procedural interventions in the remedy of obese patients with sort 2 diabetes. HbA1c can be falsely low or high in certain patients if it is affected by irregular haemoglobin turnover, the presence of variant haemoglobins, co-current sicknesses similar to haematological problems, renal or liver disease, or the effect of some drugs. It could assist folks with diabetes relate their HbA1c to day by day glucose monitoring ranges or highlight when HbA1c is inappropriate. Site-of-care capillary blood glucose meters must be monitored by certifed quality assurance schemes. Rationale Type 2 diabetes ends in development of hyperglycaemia with time, and causes organ damage through controllable hyperglycaemia. Some of this shall be performed by the person with diabetes with glucose measurements (see Chapter 8: Self monitoring), some by website-of-care checks and some by laboratory strategies. There are suggestions for patients with steady control or these requiring changes to their remedy regimen. Laboratory guidelines and different publications address obtainable strategies and their quality implementation[4-6]. HbA provides the principle technique by which clinicians 1c can relate particular person blood glucose control to threat of complication growth and its measurement is obligatory the place affordable/obtainable and acceptable for a particular affected person.

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References:

  • https://peerj.com/articles/1920.pdf
  • http://www.cdc.gov/nceh/lead/publications/leadandpregnancy2010.pdf
  • http://site.iugaza.edu.ps/fsharif/files/2010/02/Kaplan-molecular-genetics-lecture-notes-2004.pdf
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